首页> 外国专利> Preparation of cis-6-hexadecenoic acid, useful in cosmetic and dermatological applications, involves reacting triphenylphosphonium salt with aldehyde in Wittig reaction, and saponifying the resulting ester

Preparation of cis-6-hexadecenoic acid, useful in cosmetic and dermatological applications, involves reacting triphenylphosphonium salt with aldehyde in Wittig reaction, and saponifying the resulting ester

机译:顺式-6-十六碳烯酸的制备,可用于化妆品和皮肤病学用途,涉及在Wittig反应中使三苯基phosph盐与醛反应,并将所得酯皂化

摘要

Cis-6-hexadecenoic acid is prepared by reacting a triphenylphosphonium salt with decanal or other aldehyde in a Wittig reaction, and saponifying the resulting ester. Preparation of cis-6-hexadecenoic acid of formula COOH-(CH2)4-CH=CH-(CH2)8-CH3 involves: (a) reacting either: (i) a triphenylphosphonium salt of formula R1OOC-(CH2)5-P(R2)3+X- with decanal of formula CH3-(CH2)8-CH=O, or (ii) a triphenylphosphonium salt of formula CH3-(CH2)9-P(R2)3+X- with an aldehyde of formula R1OOC-(CH2)4-CH=O in a Wittig reaction; and (b) saponifying the resulting ester of formula R1OOC-(CH2)4-CH=CH-(CH2)8-CH3. R11-12C alkyl or aryl; R2aryl; X-anion equivalent of (in)organic acid.
机译:顺式6-十六碳烯酸是通过使三苯基phosph盐与癸醛或其他醛在维蒂希反应中反应,并将所得酯皂化而制备的。式COOH-(CH2)4-CH = CH-(CH2)8-CH3的顺式-6-十六碳烯酸的制备涉及:(a)使以下任何一种反应:(i)式R1> OOC-(CH2)的三苯基phosph盐5-P(R2>)3+> X->,具有式CH3-(CH2)8-CH = O的癸醛,或(ii)式CH3-(CH2)9-P(R2>)3的三苯基phosph盐在Wittig反应中+> X->与式R1的醛> OOC-(CH2)4-CH = O; (b)皂化所得的式R1的酯> OOC-(CH 2)4 -CH = CH-(CH 2)8 -CH 3。 R1> 1-12C烷基或芳基; R2>芳基; X->有机酸的阴离子当量。

著录项

  • 公开/公告号DE10105799A1

    专利类型

  • 公开/公告日2002-08-08

    原文格式PDF

  • 申请/专利权人 BASF AG;

    申请/专利号DE2001105799

  • 申请日2001-02-07

  • 分类号C07C51/09;C07C51/353;C07C57/03;

  • 国家 DE

  • 入库时间 2022-08-22 00:27:09

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