NEW TOPICAL ESTRO-PROGESTIVE COMPOSITIONS WITH SYSTEMIC EFFECT

摘要

The present invention relates to the field of therapeutic chemistry and more specifically to the production of new dosage forms intended to be applied to the skin. It relates more particularly to a topical hormonal composition with systemic effect for the hormonal treatment of perimenopause and menopause as well as for the treatment of hormonal ovarian deficit in women with amenorrhea, characterized in that it comprises, by way of active principles, a progestogen derived from 19-nor progesterone and estradiol or one of its derivatives, a vehicle which allows the systemic passage of said active principles, chosen from the group consisting of a solubilizing agent, an absorption promoting agent, a film-forming agent, a gelling agent and their mixtures, in combination or in mixture with excipients suitable for the production of a gelled and / or film-forming pharmaceutical form.