Compositions for identifying agents that modify the interaction of such determination and the interaction of the mitochondrial components and methods

摘要

(57) a composition for identifying an agent that alters SUMMARY mitochondrial membrane permeability change and methods are provided. In general, the screening method for identifying an agent that alters the interaction between cyclophilin D and the mitochondrial adenine nucleotide translocator. For example, such agents may be used to treat various conditions associated with mitochondrial function has been changed. In one aspect, the invention also relates to a nucleic acid expression construct, the construct, poly encoding the variant or mitochondrial permeability changes pore component polypeptide is fused to the variant polypeptide or further comprises a nucleotide, to the polynucleotide, the expression control sequence is operably linked, to provide a nucleic acid construct.