Tumor necrosis factor receptor 6α and tumor necrosis factor receptor 6β

摘要

The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6 alpha and -6 beta proteins. TNFR-6 alpha and -6 beta polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6 alpha and -6 beta activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.