PROTEIN HAVING GPI ANCHOR PROTEIN COMPLEX BIOSYNTHESIS- PROMOTING ACTIVITY, GENE ENCODING THE PROTEIN, GPI ANCHOR PROTEIN COMPLEX BIOSYNTHESIS INHIBITOR SCREENING KIT USING THE PROTEIN

摘要

PROBLEM TO BE SOLVED: To provide a protein which has a GPI anchor protein complex biosynthesis-promoting activity and can be used for screening a GPI anchor protein complex biosynthesis inhibitor effective as a medicine for treating various diseases such as African sleeping sickness, Chagas' disease and eishmaniasis, to provide a gene comprising a DNA encoding the protein, to provide a method for screening the GPI anchor protein complex biosynthesis inhibitor, and to provide a kit for screening the GPI anchor protein complex biosynthesis inhibitor.;SOLUTION: This protein is characterized by being one among the following proteins (a), (b) and (c). (a) A protein comprising a specific amino acid sequence originated from a protozoa, (b) a protein comprising a specific amino acid sequence, and (c) a protein which comprises an amino acid sequence having a homology of 25% in an amino acid sequence region comprising 100 amino acids in the amino acid sequence of either of the proteins (a) and (b) and has the GPI anchor protein complex biosynthesis-promoting activity.;COPYRIGHT: (C)2003,JPO