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Hydroxamic acid thrombospondin peptide analog that inhibits aggrecanase activity
Hydroxamic acid thrombospondin peptide analog that inhibits aggrecanase activity
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机译:抑制聚集蛋白聚糖酶活性的异羟肟酸血小板反应蛋白肽类似物
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摘要
The present invention concerns the generation of hydroxamic acid thrombospondin-peptide analogs that inhibit aggrecanase activity. These analogs are useful in the treatment of diseases characterized by cartilage degradation, such as osteoarthritis, rheumatoid arthritis spondylarthropathies, and septic arthritis. The invention describes a novel small molecule, enzyme inhibitor that binds both the enzyme and its naturally occurring substrate.
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