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Novel nucleic acids and polypeptides which resemble Rho and which interact with cell signalling pathways and proteins
Novel nucleic acids and polypeptides which resemble Rho and which interact with cell signalling pathways and proteins
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机译:类似于Rho并与细胞信号传导途径和蛋白质相互作用的新型核酸和多肽
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摘要
The present invention relates to an isolated full-length Chp polypeptide, a biologically-active polypeptide fragment thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction pathways, including, e.g., a PAK regulatory domain binding activity, a PAK kinase stimulatory activity, a JNK kinase stimulatory activity, a cytoskeletal-reorganizing activity, or a Chp-specific immunogenic activity. The invention relates to all aspects of Chp, or homologs thereof, including assays for modulators, activators, ligands, etc.
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