Regulated gene in the pathophysiology of ischemic stroke

摘要

The present invention identifies the K11 gene, whose gene products can be modulated to provide a protective effect against stroke, especially ischemic stroke, epilepsy and neurodegenerative disorders and enhancement of memory function. Further, the invention provides methods for diagnosing or assessing an individuals susceptibility to a stroke. Also provided are therapeutic methods for treating a stroke patient or methods for prophylactically treating an individual susceptible to stroke. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have suffered a stroke or that are at risk for stroke.