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Methods and compositions for the stimulation of human immunodeficiency virus-specific cytotoxic T lymphocytes employing autologous antigen-peripheral blood mononuclear cells
Methods and compositions for the stimulation of human immunodeficiency virus-specific cytotoxic T lymphocytes employing autologous antigen-peripheral blood mononuclear cells
A novel method of immunization, which can be used either prophylactically or therapeutically, is described. The method comprises coating of antigen presenting cells with a peptide and administering the peptide-coated cells to a mammalian subject to provoke an immune response. Useful peptides include peptides derived from viral or bacterial antigens or mutant oncogene or tumor suppressor gene products. Immunogens, constituted by the peptide-coated cells, are also described.
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