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Artemisinin analogs having antimalarial, antiproliferative, and antitumor activities and chemoselective methods of making the same
Artemisinin analogs having antimalarial, antiproliferative, and antitumor activities and chemoselective methods of making the same
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机译:具有抗疟疾,抗增殖和抗肿瘤活性的青蒿素类似物及其化学选择方法
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摘要
Methods for producing novel artemisinin analogs and artemisinin dimers having antimalarial, antiproliferative and antitumor activities are described herein. These novel artemisinin analogs and artemisinin dimers have the following structure ;or diastereomers thereof, having antimalarial, and antiproliferative and antitumor activities wherein, the monomers of the present invention are formed when n is I and R is alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl. The dimers of the present invention are formed when n is 2 and R is a linker including, but not limited to, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl or heteroaryl.
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