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Radioactive medical devices and methods of making radioactive medical devices

机译:放射性医疗器械及其制造方法

摘要

This invention involves radioactive medical devices for inhibiting an undesirable hyperplastic response in biological tissue, and a method for making the radioactive medical devices. In a first preferred embodiment, a medical device for inhibiting a hyperplastic response in biological tissue generally comprises polymeric hydrocarbon molecules forming the medical device and a salt or an acid of a radioactive isotope occluded within the polymeric hydrocarbon molecules. In a second preferred embodiment, the medical device comprises a thrombogenic sponge having a radioisotope trapped within the structure of the sponge. Also in a preferred embodiment, a method of creating a medical device according to the present invention comprises: providing a first solvent in a container; introducing a salt or an acid of a radioactive isotope into the first solvent; introducing a second solvent into the first solution so as to form a second solution; and introducing the medical device into the second solution, wherein the ionic components of the radioactive isotope migrate into the molecular structure of the medical device. In another aspect, a method of creating a medical device that inhibits a hyperplastic response in biological tissue comprises placing a salt or an acid of a radioactive isotope in a fluid and permitting the salt or acid to disassociate in solution, submersing the sponge in the solution and permitting the radioactive isotopes to become trapped in the structure of the sponge.
机译:本发明涉及用于抑制生物组织中不希望的增生反应的放射性医疗装置,以及制造该放射性医疗装置的方法。在第一优选实施方案中,用于抑制生物组织中增生性反应的医疗装置通常包括形成医疗装置的聚合烃分子和在聚合烃分子内闭塞的放射性同位素的盐或酸。在第二优选实施例中,医疗装置包括具有血栓形成的海绵,该海绵具有被困在海绵结构内的放射性同位素。同样在优选的实施方案中,根据本发明的制造医疗器械的方法包括:在容器中提供第一溶剂;以及在容器中提供第一溶剂。将放射性同位素的盐或酸引入第一溶剂中;将第二溶剂引入第一溶液中以形成第二溶液;将医疗装置引入第二溶液中,其中放射性同位素的离子组分迁移到医疗装置的分子结构中。在另一方面,一种创建抑制生物组织中增生性反应的医疗装置的方法包括:将放射性同位素的盐或酸置于流体中,并允许该盐或酸在溶液中解离,将海绵浸入溶液中。并允许放射性同位素被困在海绵的结构中。

著录项

  • 公开/公告号US6612976B2

    专利类型

  • 公开/公告日2003-09-02

    原文格式PDF

  • 申请/专利权人 ISOTECH L.L.C.;

    申请/专利号US20010879551

  • 发明设计人 BRIAN GANNON;DAVID ROSENTHAL;

    申请日2001-06-12

  • 分类号A61N50/00;A61K510/00;

  • 国家 US

  • 入库时间 2022-08-22 00:05:40

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