Enantiomerically enriched malonic acid monoesters substituted by a tertiary hydrocarbon radical, and their preparation

摘要

The invention relates to enantiomerically enriched malonic acid monoesters -monosubstituted by a tertiary hydrocarbon radical, or their salts, of the general formula I: ;in which R¹, R³, R⁴ and R⁵ are identical or different hydrocarbon radicals, and wherein any two of the radicals R³, R⁴ and R⁵ may alternatively be present as a carbocyclic ring together with the quaternary carbon atom which they substitute, and M is hydrogen, one equivalent of a metal or an optionally substituted ammonium ion. The invention further relates to a process for the preparation of the enantiomerically enriched -monosubstituted malonic acid monoesters, or their salts, by enzymatic partial hydrolysis of the corresponding diesters.