Medicament for treating at least one of the two states being represented by preeclampsia and preterm labor in a pregnant female mammal and pharmaceutical preparation

摘要

In the present invention there is disclosed the use of a combination of (a) progestin and (b) nitric oxide synthase substrate and/or nitric oxide donor, or both, optionally in further combination with one or more compounds being selected from the group consisting of cyclooxygenase inhibitors, PGIi2 -mimetics, thromboxane (TXAi2) inhibitors, a compound possessing TXAi2-agonistic and TXAi2 -inhibiting properties, a compound possessing TXAi2 -antagonistic and PGIi2-mimetic activities, and a TXAi2-antagonist, for preparing a medicament intended for treating at least one of the two state being represented by preeclampsia and preterm labor in a pregnant female mammal. The invention relates also to a pharmaceutical preparation containing the above-indicated combination in an amount effective for alleviation of symptoms of preeclampsia, toxemia or preterm labor in a pregnant female mammal symptoms for administering to a female in need of such treatment progestin in bio-equivalent amount of 50 to 300 mg of injected progesterone and the nitric oxide synthase substrate, nitric oxide donor, or both, wherein the amount of nitric oxide synthase substrate is effective to raise the blood level of circulating L-arginine to at least about 1 mmole above the normal circulating level of L-arginine and wherein the amount of nitric oxide donor is effective to provide a blood level of such donor of about 1-1000 nmole.