ANTIBODY COMPETITON BINDING ASSAY FOR QUALITATIVE DETECTION OF THE CONFORMATION CHANGES AND CONFORMATION-DEPENDENT QUANTITATIVE DETECTION OF GLYCOPROTEIN P AND OTHER CELL SURFACE RECEPTORS, PUMPS AND PROTEINS, AND USES THEREOF

摘要

the object of the invention is the procedure the presence of cell surface receptors, pumps and / or vagyfehu00e9rju00e9k konformu00e1ciu00f3 change detection, in which at least twodifferent antibodies and, where appropriate, ligandumot bound to the antibodies recognized by receptors, pumpu00e1khoz and / or bound to proteins, and the antitestku00f6tu0151du00e9svu00e1ltozu00e1sait is measured.the method can be used for determination of resistance to cytostatic multidrog esetu00e9nhatu00e1sos natu00edvsejteket combination, where the active substance to be tested in vitro.active substance combination and inkubu00e1lnak, then the sample elju00e1ru00e1snakvetik under the above test.this procedure is effective for the detection of modulu00e1torokhatu00e9konysu00e1gu00e1nak multidrog resistance may be used, if the procedure is known to be tested, and the modulator is carried out in the presence of.and compared with the kapottaktivitu00e1su00e9rtu00e9keket.the invention also tu00e1rgyadiagnosztikai kit cell surface receptors, pumps or fehu00e9rju00e9kjelenlu00e9tu00e9nek and konformu00e1ciu00f3 change detectionin the case of multidrog resistance effective combination or the effectiveness of detection meghatu00e1rozu00e1su00e1rau00e9s / modulators, in which a first areceptorokat,pumps or proteins capable of recognizing a second antibody, the receptors or proteins to recognize ku00e9pesantitestet, pumps, and, where appropriate, the additional ligandumot, aa system suitable for the ku00f6tu0151du00e9smu00e9ru00e9su00e9re contains. oh