PROCESS FOR PRODUCTION ISOXAZOLE-4-CARBOXYLIC ACID AMIDES AND HYDROXI-ALKYLIDENE-CYANIC-ACETIC ACID AMIDES PHARMACEUTICAL PREPARATIONS HAVING THESE COMPOUNDS AND THE KNOWN COMPOUNDS WITH ANTICANCER ACTIVITY

摘要

The present invention relates to anticancer compositions comprising novel and known compounds, in particular isoxazole-4-carboxamides of formula (I), (Ia) and (Ib) and hydroxyalkylidene cyanoacetic acid amides, and to novel (I), For the preparation of compounds of formulas Ia) and (Ib). The compounds have anti-cancer activity and the new compounds also have anti-rheumatic activity. ŕ