CELL SPECIFIC AND OR TUMOR SPECIFIC PROMOTER RETARGETING OF HERPES GAMMA 34.5 GENE EXPRESSION.

摘要

The present invention relates to herpes viral mutants and methods of using these viral mutants for selectively targeting tumor cells or other populations of target cells. The viral mutants of the invention are capable of selective targeting due to the use of tumor specific and or cell specific promoters to drive expression of the herpes ggr;34.5 gene.