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Formulering basert på heparin, glykosaminoglykan eller heparinoid, anvendelse av formuleringen og formuleringsbasen
Formulering basert på heparin, glykosaminoglykan eller heparinoid, anvendelse av formuleringen og formuleringsbasen
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机译:基于肝素,糖胺聚糖或类肝素的制剂,制剂的用途和制剂基质
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摘要
The invention relates to formulations based on at least one heparin, one glycosaminoglycan or on one heparinoid, and to a formulation base with a lipid constituent and a polymer constituent. The invention also relates to the use of this formulation as a medicament for orally administering at least one heparin, one glycosaminoglycan or one heparinoid, and to a method for preparing the formulations by mixing the formulation constituents while forming a plastic mixture and, optionally, while preparing the formulations as a medicament while, advantageously, using melt extrusion. The lipid constituent advantageously comprises active substance-promoting properties, whereas the polymer constituent is soluble or is capable of swelling. The invention provides that at least portions of the lipid constituent are embedded in a polymer matrix, preferably in molecularly dispersed form. The formulations can form emulsions in water or in aqueous fluids.
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