Cytokines or growth factors linked to agents which control cell proliferation and pharmaceutical use

摘要

A product comprising a proliferatively active moiety, typically a cytokine or growth factor which has a high affinity receptor, linked to a biologically active agent which agent preferentially or selectively affects proliferating cells. An active promoter of proliferation, for example an active IL-2, is beneficially used to deliver pharmacologically desirable species to cells whose proliferation is not desired. For example some medicaments of the invention control or inhibit proliferation using a molecule which contains an active promoter of proliferation. The biologically active agent is usually selected from the group consisting of antiproliferative drugs, compounds which interfere with nucleotide synthesis, radioisotopes, gene sequences and antisense nucleotide sequences.