Topical water-in-oil anaesthetic formulation for use in pain management

摘要

The topical pharmaceutical water-in-oil composition in form of a cream or lotion, comprising (i) 2-50% of a local anaesthetic in oil form in the final composition, or two or more local anaesthetics forming an oil when mixed together, effective to produce a topical anaesthetic effect upon administration; (ii) 2-50% of a water-in-oil emulsifier, effective to produce an emulsion of the desired viscosity; and (iii) 2-96% water. Optionally the composition may contain up to 20% of pharmaceutically acceptable stabilizers or penetration enhancers. This novel pharmaceutical composition is useful in therapy, in particularly for the treatment of pain