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CHANGED IMMUNOGLOBULINE FOR SPECIFIC FC-EPSILON RECEPTORS
CHANGED IMMUNOGLOBULINE FOR SPECIFIC FC-EPSILON RECEPTORS
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机译:特定FC-ε受体改变的免疫球蛋白
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摘要
Two classes of polypeptides derived from human IgE are described. One class binds selectively to the high affinity IgE receptor on mast cells and basophils, but not to the low affinity IgE receptor on B-cells, monocytes, eosinophils and platelets. The other class binds to the low affinity receptor, but not the high affinity receptor. The differential binding polypeptides of this invention are useful in diagnostic procedures for IgE receptors or in the therapy of IgE-mediated disorders such as allergies. They also are useful in preparing antibodies capable of binding regions of IgE that participate in receptor binding.
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