PHARMACEUTICAL COMPOSITION CONTAINING A COMBINATION OF THE DEXTRO AND LAEVO ISOMERS OF SOTALOL

摘要

Antiarrhythmic composition with controlled beta -adrenergic blockade comprises a combination of dextro- and laevo-rotatory isomers of sotalol or their salts in a ratio of 1.5:1-3.5:1. An independent claim is included for an oral or parenteral composition for treating cardiac ailments which comprises a combination of dextro- and laevo-isomers of sotalol. ACTIVITY : Antiarrhythmic; cardiant. In a test using Guinea pigs (Dunken Hartley) to demonstrate antiarrhythmic activity of different ratios of sotalol, ouabain was used to produce ventricular tachycardia. Sotalol (2:1 ratio (d:l)) resulted in complete protection against ventricular tachycardia at a dosage of 2.5 mg/kg. MECHANISM OF ACTION : beta -adrenergic antagonist.