TRANSFECTION OF LUNG VIA AEROSOLIZED TRANSGENE DELIVERY

摘要

Methods and compositions for producing a mammal capable of expressing anexogenously supplied gene in cells of theairway are disclosed. Lipid carrier-nucleic acid complexes are prepared thendelivered via aerosol to the lung airway. The inven-tion provides a direct method for transforming pulmonary cells as a means fortreating disorders of the lung as for providing ameans for delivering substances systematically following expression in thelung.