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METHOD FOR DETERMINING THE INFLUENCE OF NON-PHYSIOLOGICAL COMPOUNDS THE DERIVATIVES AND DECOMPOSITION PRODUCTS THEREOF ON ORGANISMS ORGANS AND CELLS

机译:测定非生理性化合物衍生物及其分解产物对有机体和细胞的影响的方法

摘要

The invention relates to a method for determining reversible or irreversible physiological side-effects of a substance whereby said method comprises the following steps: a) preparation of a sample treated with the substance, preferably comprising a single cell or several cells in a cell structure or an organ, b) determination of cellular and/or sub-cellular patterns from regional localisations and co-localisations of at least two different molecules, in particular proteins, RNA molecules, or DNA segments, in at least one sub-population of cells, c) comparison of the pattern obtained in step b) with patterns from an untreated control sample and d) determination of a physiological side-effect of the substance by means of various patterns for a treated sample in comparison with an untreated sample.
机译:本发明涉及确定物质的可逆或不可逆的生理副作用的方法,其中所述方法包括以下步骤:a)制备用所述物质处理的样品,所述样品优选在细胞结构中包含单个细胞或几个细胞或b)从至少一个亚细胞群中的至少两种不同分子,特别是蛋白质,RNA分子或DNA片段的区域定位和共定位,确定细胞和/或亚细胞模式, c)将步骤b)中获得的图案与未处理的对照样品中的图案进行比较,d)通过与未处理的样品相比,针对已处理样品的各种图案来确定物质的生理副作用。

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