GENE EXPRESSION DATA ANALYZER, AND METHOD, PROGRAM AND RECORDING MEDIUM FOR GENE EXPRESSION DATA ANALYSIS

摘要

Gene expression doses expressed in fluorometric data, which are measured by an experiment with the use of DNA microarrays and DNA chips, of a comparative group and a control group are corrected based on a novel mathematic model. Based on the scatter plots thus corrected, a novel X-Y axis system having an x axis proprotional to the fluorescence intensity of genes is constructed. Next, windows each having a definite number of genes are made along the X-axis and the reliability limit of the arbitrary risk is determined in each window in accordance with Student’s t-distribution. Then windows are shifted by a definite number of genes in the X-axis direction and each reliability limit is determined. The plural reliability limits thus determined are complemented by smoothening (spline curve) to give a reliability curve of expression variation. Subsequently, genes located outside the reliability curve of expression variation thus obtained are extracted as variation genes.