20-0---1-6----20- Microemulsion having 20-O--L-arabinopyranosyl1-6--D-glucopyranosyl-20S-protopanaxadiol by nano-emulsion technology and skin care and pharmaceutical compositions for external applications utilizing thereof

摘要

PURPOSE: A microemulsion particle containing 20-0-£-L-arabinopyranosyl(1-6)--D-glucopyranosyl|-20(S)-protopanaxadiol separated from bioconversion of ginseng saponin is provided. The external preparation composition of skin using the same has an excellent effect of preventing skin aging, such as wrinkle improvement. CONSTITUTION: The microemulsion particle contains 10¬-8 to 99.9999% by weight of 20-0-£-L-arabinopyranosyl(1-6)--D-glucopyranosyl|-20(S)-protopanaxadiol of the formula 1 as an effective ingredient and liposome containing lecithin, lecithin derivatives and a co-emulsifier, based on the total weight of the particle. In formula, R2 is OH and R3 is H. The microemulsion particle is prepared from acid hydrolysis, base hydrolysis or enzymolysis of ginseng extract and ginseng saponin. The cosmetic and pharmaceutical composition having excellent effects of proliferating skin cells and promoting collagen biosynthesis is obtained by formulation of the microemulsion particle.