Combination preparation containing nucleoside compound and 5-sulfonyl-2-phenylacetamido-thiazole derivative, useful as antiviral agent effective againts herpes viruses, especially herpes simplex

摘要

New combination preparations (A) contain (a) nucleoside compounds (specifically acyclovir or penciclovir) and (b) 5-aminosulfonyl-2-phenylacetamido-thiazole derivatives (I) or 5-halosulfonyl-2-phenylacetamido-thiazole derivatives (IV). New combination preparations (A) contain nucleoside compounds (specifically acyclovir, penciclovir or their prodrugs) and (b) thiazole derivatives of formula (I) (or their salts) or (IV). R1 = H, halo, alkyl, alkoxy, aminoalkyl or haloalkyl; R2, R3 = H, alkoxy, cycloalkyl or biphenylaminocarbonyl; alkyl (optionally substituted (os) by 1-3 of 3-6C cycloalkyl, alkoxy, halo, OH, NH2, trialkylsilyloxy, 3,4-methylenedioxyphenyl, tetrahydrofuran-2-yl, -N(R'2)COOtBu, Het1, Het2 or aryl (os by OH or alkoxy)); -P(O)(OR8)(OR9), -COCH(NH2)-R10, -CHR11-OCOR12 or -CH(NH2)-R10; or NR2R3 = 5- or 6-membered saturated heterocycle, optionally containing a further O heteroatom; R'2, R8, R9 = H or 1-4C alkyl; Het1 = C- or N-bonded 5- or 6-membered aromatic heterocycle containing 1-3 of S, N and/or O as heteroatom(s)); Het2 = C- or N-bonded 3-8 membered, saturated or unsaturated, non-aromatic heterocycle containing 1-3 of S, N and/or O as heteroatom(s)); R10 = side-chain of a naturally occurring aminoacid; R11 = 1-4C alkyl; R12 = H, 1-4C alkyl or -CH(NH2)-R10; R4 = H, acyl, 2-6C alkenyl or cycloalkyl; or alkyl (os by 1-3 of halo, OH, cycloalkyl, acyl, alkoxy, COOH, NHCOOtBu, OEt, -CH2CH2OEt, phenoxy, aryl or NR13R14); or alkyl substituted by optionally benzo-fused Het1, 2-(R16)-pyrrolidino, tetrahydrofuran-2-yl, benzo-1,4-dioxan-2-yl, 2-oxo-pyrrolidino or -OCOR17R18; R13, R14 = H, acyl, alkyl, CONH2, mono- or dialkylaminoalkyl, mono- or dialkylaminocarbonyl, aryl or alkoxycarbonyl; or NR13R14 = 5- or 6-membered saturated heterocyclyl, optionally containing a further O, S or NR15 heteroatom and os by =O; R15 = H or 1-4C alkyl; R16 = H or alkyl; R17, R18 = H; or alkyl or aryl (both os by 1-3 of OH, alkoxy or halo); R5, R7 = H, alkyl, halo, NH2, mono- or dialkylamino or alkanoylamino; R6 = phenyl (os by 1-3 groups R'6); R'6 = halo, aryl (os by 1-3 of alkanoyl, alkoxy, alkyl, halo, alkoxycarbonyl, NO2, haloalkyl, haloalkoxy, NH2, alkylthio, OH, COOH, CONH2, mono- or dialkylaminocarbonyl, mono- or dialkanoylamino, alkoxycarbonylamino, alkylsulfoxy, alkylsulfonyl, trialkylsilyloxy, Het2 or CN), alkoxy (os by 1-6 F, but not perfluorinated), alkoxycarbonyl, alkylthio, OH, COOH, alkyl (os by tetrahydrofuran-2-yl), Het1 (os by 1-3 of alkanoyl, alkoxy, alkyl, halo, alkoxycarbonyl, NO2, haloalkyl, haloalkoxy, NH2, alkylthio, OH, COOH, CONH2, mono- or dialkylaminocarbonyl, mono- or dialkanoylamino, alkoxycarbonylamino, alkylsulfoxy, alkylsulfonyl, Het2 (mono- or bicyclic) or CN), Het2 (mono- or bicyclic; and os by 1-3 of =O, halo, OH, alkoxycarbonyl, alkoxycarbonylamino, alkyl, haloalkyl or hydroxyalkyl), 2-6C alkenyl, OR19, NR20R21, CONR22R23, carbazole, dibenzofuran, dibenzothiophene, xanthene or 9,10-dihydroacridine; R19 = phenyl (os by NR24R25) or alkyl (os by 1-3 of OH or halo); R24, R25 = H, alkyl or acyl; R20, R21 = H, CONH2, mono- or dialkylaminocarbonyl, phenyl, acyl or alkyl (os by alkoxy or acyl; or by phenyl or Het1 (both os by 1-3 of halo or OH)); R22, R23 = H or alkyl; D = halogen; alkyl moieties or acyl groups have 1-6C, cycloalkyl moieties 3-8C and aryl moieties 6-10C unless specified otherwise.