Preparation of organodiphosphonites, useful for the production of catalysts, comprises reaction of an organo phosphorous chloride with an alcohol, treatment of the product with an organic base and addition of a (hetero)aryl diol

摘要

Preparation of organodiphosphonites comprises reaction of one mole of an organo phosphorous chloride with one mole of an alcohol in the absence of an organic base at -25 to +10 deg C, treatment of the product with at least one equivalent of an organic base, and addition of a (hetero)aryl diol. A process for the production of organodiphosphonites of formula (I) comprises: (a) reaction of one mole of R2PCl2 with one mole of R1OH in the absence of an organic base at -25 to +10 deg C; (b) treatment of the product from step (a) with at least one equivalent of an organic base (with respect to (w.r.t.) R2PCl2) to yield (R1-O)R2PCl and an essentially insoluble salt of the organic base with HCl, at -25 to +10 deg C; and (c) reaction of (R1-O)R2PCl) with a compound HO-Z-OH, where in the case that less than two equivalents of base were added in step (b), further base is added in an amount such that at least two equivalents (w.r.t. one mole of R2PCl2) are added in steps (a), (b) and (c) at -25 to +10 deg C. (R1-O)R2P-O-Z-O-PR2(O-R1) (I) R1, R2 = optionally substituted aryl, heteroaryl, 4-8C cycloalkyl or 1-10C alkyl; Z = optionally substituted arylene, heteroarylene, 4-8C cycloalkylene or 1-10C alkylene.