Composition useful for treating respiratory disease, comprises a peptide that activates guanylate cyclase C, and is delivered to the apical membrane through the respiratory tract

摘要

Medicine (A), in a formulation that is delivered to the apical membrane of mucosal epithelial cells through the respiratory tract, contains at least one peptide (I) that activates guanylate cyclase C (GCC). Independent claims are also included for the following: (1) Inhalation device containing (A); and (2) Diagnosing diseases that are accompanied by breathing disorders or disorders of mucus secretion in the respiratory tract, by detecting at least one (I). - ACTIVITY : Antiasthmatic; Antiinflammatory. No details of tests for these activities are given. - MECHANISM OF ACTION : Stimulation or activation of GCC, a G protein-coupled receptor that catalyzes conversion of guanosine triphophate to cyclic guanosine monophosphate (cGMP) and is present on the apical (air) side of respiratory epithelial cells but not on the basolateral (blood) side. cGMP activates membrane-associated type II protein kinase which in turn activates the regulatory domain of the cystic fibrosis transmembrane conductance regulator, resulting in secretion of chloride ions and water from the cells, causing fluidization of the mucus. No biological data given.