ANTI-DNA ANTIBODY DETECTION BY DETECTING AND BINDING TELOMERIC DNA SEQUENCES

摘要

The invention relates to a diagnostic method for detection of anti-DNA antibodies in patients with lupus erythematosus, particularly SLE, test kit, solid phase means and a therapeutic method and a drug. All these applications are characterised by the use of telomeric DNA sequences able to bind specifically to anti-DNA-antibodies. Preferred antibody-binding telomeric sequences comprise 5'-TTAGGG-3', 5'-CCCTAA-3', repeats thereof or double stranded vertebrate telomere. Solid phase removal of anti-DNA antibodies with solid phase bound telomeric sequences and use of the telomeric sequences as a drug for treatment of patients with autoimmune disorders are revealed.