Using oxidized lipoprotein to induce maturation of monocytes to dendritic cells, useful in treatment or prevention of cancer, in vivo or in vitro

摘要

Use of at least one oxidized lipoprotein fraction (A) to induce in vitro differentiation of monocytes to mature dendritic cells (MDC). (A) are oxidized very low (VDL), intermediate (IDL) and/or low (LDL) density lipoproteins. Independent claims are also included for: (1) use of (A) for preparing a pharmaceutical composition for inducing differentiation of monocytes to MDC; (2) process for in vitro differentiation of monocytes to MDC by treatment with (A); (3) produced MDC; and (4) active agent for inducing differentiation of monocytes to MDC comprising (A).