GENETIC DIAGNOSIS OF HYPERTENSION USING POLYMORPHISM IN ENDOTHELIN 1 GENE AND NUCLEIC ACID MOLECULE FOR USE IN THE DIAGNOSIS

摘要

PROBLEM TO BE SOLVED: To provide a nucleic acid probe and a primer for use in the genetic diagnosis of hypertension.;SOLUTION: A nucleic acid molecule as the probe or primer, which is capable of identify whether the 30th nucleotide in the 2nd intron is thymine(T) or guanine(G) in endothelin-1 gene and to be used in predicting or diagnosing hypertension, comprises a nucleotide fragment hybridizable with a polynucleotide encoding a protein comprising an amino acid sequence represented by Sequence No.3 or a polynucleotide complementary thereto.;COPYRIGHT: (C)2004,JPO