首页> 外国专利> Schizophrenia-like mental disease model animal, method of constructing the same and use thereof

Schizophrenia-like mental disease model animal, method of constructing the same and use thereof

机译:精神分裂症样精神疾病模型动物,其构建方法及其用途

摘要

The present invention relates to a schizophrenia-like cognitive dysfunction animal model; a method of preparing the same; and a method of evaluating schizophrenia-like cognitive dysfunction by using said model. Specifically, the present invention relates to the preparation of a mammal showing continuous cognitive abnormality after sexual maturation, by allowing an excessive presence of interleukin 1 or an analog thereof and/or an intracellular signal transducer induced by interleukin 1 or an analog thereof in the body of young animal during the stages of brain function development; and a method of evaluating cognitive dysfunction by ethologically measuring the cognitive abnormality in the animal.
机译:本发明涉及精神分裂症样认知功能障碍动物模型。一种制备方法;和通过使用所述模型评估精神分裂症样认知功能障碍的方法。具体地,本发明涉及通过允许体内白介素1或其类似物和/或由白介素1或其类似物诱导的细胞内信号转导子的过量存在而在性成熟后表现出连续认知异常的哺乳动物的制备。在脑功能发展阶段的幼兽以及通过从伦理学上测量动物的认知异常来评估认知功能障碍的方法。

著录项

  • 公开/公告号US2004103447A1

    专利类型

  • 公开/公告日2004-05-27

    原文格式PDF

  • 申请/专利权人 NAWA HIROYUKI;OKA MAKOTO;

    申请/专利号US20030469165

  • 发明设计人 MAKOTO OKA;HIROYUKI NAWA;

    申请日2003-10-01

  • 分类号A01K67/027;

  • 国家 US

  • 入库时间 2022-08-21 23:19:58

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