Outer membrane vesicle (omv) vaccine comprising neisseria meningitidis serum group b outer membrane proteins

摘要

"EXTERNAL MEMBRANE VESICLE (OMV) VACCINIA UNDERSTANDING NEISSERIA MENINGITIDIS SERIES GROUP B EXTERNAL MEMBRANE PROTEINS". A composition comprising (a) Neisseria meningitidis serum group B outer membrane vesicles (OMVs) and (b) a selected immunogenic component or among other Neisseria proteins or immunogenic fragments thereof. Component (b) preferably includes a protein from a different NmB strain from which the OMVs of component (a) are derived. OMVs are preferably obtained by deoxycholate extraction. Optionally, the composition may also comprise a protective antigen against other pathogens.