Methods for regulating an immune response mediated by cells by blocking signals linfocu00ecticos and by blockade of adhesion mediated by LFA-1

摘要

Methods for regulating an immune response mediated by DP cells by blocking signals linfocu00ecticos and by blockade of adhesion mediated by LFA-1.The invention provides methods to regulate immune responses mediated by cells.Diseases of the immune system and transplant rejection of allograft by interfering in the interaction of at least three molecules of cell surface of different with their natural ligands.A first cell interaction is mediated by CD28 / B7 / CTLA4, a second interaction is mediated by CD40 / CD154, and a third interaction is mediated by the interaction of LFA-1 with its ligands.The regulation of an immune response mediated by cells affects the diseases of the immune system such as those associated with the transplantation of allograft.