Compound, pharmaceutical composition, method for inhibiting rna-dependent rna viral polymerase and / or inhibiting rna-dependent rna viral replication, method for treating an rna-dependent rna viral infection, and use of a compound

摘要

"COMPOSITION, PHARMACEUTICAL COMPOSITION, METHOD FOR INHIBITING RNA DEPENDENT RNA VIRAL POLYMERASE AND / OR INHIBIT RNA DEPENDENT RNA VIRAL REPLICATION, METHOD FOR TREATING A RNA COMPONENT VIRAL INFECTION, AND, USE OF" The present invention provides nucleoside compounds and certain derivatives thereof which are RNA-dependent RNA viral polymerase inhibitors. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for treating RNA-dependent RNA viral infection. These are particularly useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, as HCV replication inhibitors and / or for the treatment of hepatitis C infection. The invention also discloses pharmaceutical compositions containing such nucleoside compounds alone or in combination with other active agents against RNA-dependent RNA viral infection, in particular HCV infection. Methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication and / or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention are also disclosed.