Chimeric gene, chimeric protein, recombinant virus, vaccine composition, use of a vaccine composition, therapeutic or preventive combination, and plasmid

摘要

"CHEMICAL GENE, CHEMICAL PROTEIN, RECOMBINANT VIRUS, VACCINE COMPOSITION, USE OF A VACCINE COMPOSITION, THERAPEUTIC OR PREVENTIVE COMBINATION, AND PLASMIDE". Chimeric HIV genes formed by the binding of fragments of different genes of this virus are described, and these fragments contain cytotoxic T-cell (CTL) or T-helper epitopes epitopes, which are presented by a wide range of HIV antigen. Type 1 Human Histocompatibility Main System (HLA-1). From these genes recombinant poxviruses are obtained which are useful for prophylactic and therapeutic vaccination against HIV / AIDS infection capable of generating a protective cellular immune response in immunized laboratory animals and being recognized by the CTL lymphocytes of HIV / AIDS patients.