Controlled dosage release element and methods for releasing at least one first active agent into the rumen of a ruminant animal, for treatment, prophylaxis or both of an infested or unhealthy state in a ruminant animal and for alteration of the physiological state of a ruminant animal

摘要

"CONTROLLED DOSAGE RELEASE ELEMENT, AND METHODS FOR RELEASE AT LEAST ONE FIRST ACTIVE AGENT WITHIN THE RUMIN OF AN RUMINANT ANIMAL, FOR TREATMENT, PROPHILAXY OR BOTH OF AN INFESTED STATE OR ANIMAL ARMY THE CHANGE OF THE PHYSIOLOGICAL STATUS OF A RUMINATING ANIMAL ". The present invention relates to a controlled dosage release member adapted to be inserted and retained within the rumen of a ruminant animal. The element comprises: a) one or more predetermined and distinct amounts of at least one first formulation comprising at least one first active agent, the formulation being adapted to dissolve in rumen fluids at a rate such that the dissolution of each of a or more amounts of the first formulation provide a pulsed or short episode of release of the first active agent into the rumen; b) one or more predetermined amounts of at least one second formulation adapted to dissolve at a controlled rate in rumen fluids; wherein one or more first formulation amounts are provided at one or more predetermined locations within the element with respect to said one or more second formulation amounts for one or more delayed releases of at least the first active agent into the rumen. predetermined times before, during, after, or in any combination thereof, of a predetermined extended period of time defined by said second formulation. The invention also relates to a method for releasing at least one first active agent into the rumen of a ruminant animal in a delayed manner at one or more predetermined times following administration to the animal of a composition containing the active agent, the method comprising administering to the animal a controlled dosage release element according to the invention. The first active agent will typically be for the treatment, prophylaxis or both of an infested or unhealthy state in a ruminant animal, or for altering the physiological state of a ruminant animal.