Vaccine composition of epidermal growth factor in vesu00cdculas liposomal Encapsulated with Antitumor Activity

摘要

The present Invention relates to the field of Immunology and, More specifically, with the production of a vaccine composition of epidermal growth factor receptor (EGFR) with Antitumor Activity using liposomal vesicles as adjuvant.The present Invention is characterized in the composition in the EGF immobilized loiposomas combining or not to a "carrier" (proteu00edco p64k protein of Neisseria meningitidis, obtained via recombinant) in a molar ratio appropriate, to induce a humoral immune response anti EGF EQUAL or improved the already obtained with other adjuvants.The vaccine composition is used in active Immunotherapy of malignant tumors overexpressing cells on the surface of the epidermal growth factor receptor (egf-r), thus inhibiting their growth.