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An important sequence analysis from the effective law of Republika Srpska and the protective umbrella of Republika Srpska

机译:从斯普斯卡共和国有效法律和斯普斯卡共和国保护伞的重要序列分析

摘要

The invention relates to peptides from CPS binding protein,According to the scheme, the sequence of amino acid substitutes (A.A.) was introduced to ensure the enhancement of cell activation capacity dependent on CPS in vitro and in vivo, and to show the benefits of using the substance to improve endocrine disorders, especially endocrine disorders. Systemic inflammation. These peptides are produced by amphibious proteinsHigh density of amino acids and positive and negative charges. The invention determines the exposure of specific amino acids at specific locations in these cucumber sequences to ensure their activity and power. These peptides affect the binding of CPS and LPP, and inhibit the production of human leukemia cells induced by CPS. In addition, these peptides can protect mice allergic to d-activator from the lethal dose of drug resistance. The invention also includes the use of inhibitory peptides and related molecules in the treatment of endocrine related diseases,A pharmaceutical component containing one or more peptides and their derivatives, and a diagnostic method for one or more peptides used in the invention.
机译:本发明涉及来自CPS结合蛋白的肽,根据该方案,引入氨基酸替代物(AA)的序列以确保增强依赖于CPS的体外和体内细胞活化能力,并显示出使用CPS的益处。改善内分泌疾病,特别是内分泌疾病的物质。全身性炎症。这些肽是由两栖蛋白产生的,氨基酸密度高,带正电荷和负电荷。本发明确定了在这些黄瓜序列中特定位置上特定氨基酸的暴露,以确保其活性和功效。这些肽影响CPS和LPP的结合,并抑制由CPS诱导的人白血病细胞的产生。此外,这些肽可以保护对d-激活剂过敏的小鼠免于致死剂量的耐药性。本发明还包括抑制性肽和相关分子在治疗内分泌相关疾病中的用途,包含一种或多种肽及其衍生物的药物成分以及用于本发明的一种或多种肽的诊断方法。

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