NOVEL FKA-25 SUBSTANCE HAVING INHIBITORY ACTION AGAINST FORMATION OF THE FOAM MACROPHAGE AND A PROCESS FOR PRODUCTION THEREOF

摘要

The present invention relates to a novel FKA-25 substance,which inhibits formation of the foam macrophage originated frommouse, having inhibitory action against formation of the foammacrophage and a process for production thereof. The processincludes culturing Pseudobotrytis sp. FKA-25 belonging to genusPseudobotrytis sp. and having ability to produce FKA-25substance in a medium, accumulating FKA-25 substance in thecultured medium, and collecting FKA-25 substance from thecultured mass. The obtained FKA-25 substance specificallyinhibits the formation of the foam macrophage originated frommouse and is expected to be useful for prevention and treatmentof arteriosclerosis and causative diseases therefrom.