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INTRAVENOUS NANOPARTICLES FOR TARGETING DRUG DELIVERY AND SUSTAINED DRUG RELEASE
INTRAVENOUS NANOPARTICLES FOR TARGETING DRUG DELIVERY AND SUSTAINED DRUG RELEASE
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机译:靶向给药和维持药物释放的静脉注射纳米颗粒
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摘要
Provided are poly(lactic-co-glycolic acid) (PLGA) and poly(lactic acid) (PLA)nanoparticles that encapsulate a low~ molecular weight and water-soluble drugand can deliver the drug to target legion sites where the particles graduallyrelease the drug over a prolonged period of time. The nanoparticles areprepared by allowing the low-molecular, water-soluble and non-peptide drug tointeract with a metal ion so as to make the drug hydrophobic, encapsulatingthe hydrophobicized drug into PLGA or PLA nanoparticles, and allowing asurfactant to be adsorbed onto the surface of the particles.
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