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Calcium salts of 1,5-benzodiazepine derivatives, process for producing the salts and drugs containing the same

机译:1,5-苯并二氮杂卓衍生物的钙盐,其制备方法和含有该盐的药物

摘要

Provided are calcium salts of a 1,5-benzodiazepine derivative represented by the following formula (I): CHEM (wherein, R1 represents a lower alkyl group, R2 represents a phenyl or cyclohexyl group, and Y represents a single bond or a lower alkylene group); a process for preparing the salts; and drugs containing the same as the active ingredient. The compounds exhibit a potent inhibitory activity against the secretion of gastric acid and potent antagonism against gastrin and/or CCK-B receptor.
机译:提供由下式(I)表示的1,5-苯并二氮杂derivative衍生物的钙盐:(其中,R 1代表低级烷基,R 2代表苯基或环己基,并且Y表示单键或低级亚烷基);制备盐的方法;以及含有与有效成分相同的药物。所述化合物对胃酸的分泌表现出有效的抑制活性,对胃泌素和/或CCK-B受体具有强烈的拮抗作用。

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