TRANSGENIC MICE CONTAINING PROTEASE TARGET GENE DISRUPTIONS

摘要

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a protease target gene, such as CAPN5 gene, a tryptase 4 gene, or a sialoglycoprotease-like gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.