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SYNTHESIS OF 2H1,13C, 2H2, 13C AND 2H3, 13CMETHYL ARYL SULFONES AND SULFOXIDES
SYNTHESIS OF 2H1,13C, 2H2, 13C AND 2H3, 13CMETHYL ARYL SULFONES AND SULFOXIDES
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机译:[2 H 1,13 C],[2 H 2,13 C]和[2 H 3,13 C]甲基芳基砜和磺酰胺的合成
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摘要
The present invention is directed to labeled compounds, [2H1, 13C], [2H2, 13C] and [2H3, 13C]methyl aryl sulfones and [2H1,13C], [2H2, 13C] and [2H3, 13C]methyl aryl sulfoxides, wherein the 13C methyl group atatched to the sulfur of the sulfone or sulfoxide includes exactly one, two or three deuterium atoms and the aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure wherein RI, R2, R3, R4 and R5 are each independently, hydrogen, a Cl-C4 lower alkyl, a to halogen, an amino group from the group consisting of NH2, NHR and NRR' where R and R' are each a Cl-C4 lower alkyl, a phenyl, or an alkoxy group. The present invention is also directed to processes of preparing methyl aryl sulfones and methyl aryl sulfoxides.
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机译:本发明涉及标记的化合物,[2 H 1,13 C],[2 H 2,13 C]和[2 H 3,13 C]甲基芳基砜和[ 2 H 1,13 C],[2 H 2,13 C]和[2 H 3,13 C]甲基芳基亚砜,其中13 C甲基附着于硫的砜或亚砜恰好包括一个,两个或三个氘原子,并且芳基选自1-萘基,取代的1-萘基,2-萘基,取代的2-萘基和具有以下结构的苯基: ,R 2,R 3,R 4和R 5各自独立地为氢,C 1 -C 4低级烷基,至卤素,选自NH 2,NHR和NRR'的氨基,其中R和R'各自为Cl-C4低级烷基,苯基或烷氧基。本发明还涉及制备甲基芳基砜和甲基芳基亚砜的方法。
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