A packed-bed bioreactor for producing high concentration spores and culturing method thereby

摘要

PURPOSE: A packed-bed bioreactor for producing high concentration spores through solid cultivation and a culturing method using the same are provided, thereby inhibiting the reduction of microorganism growth area, prevention of ventilation, and accumulation of metabolism heat, and consequently producing high concentration spores over the bioreactor. CONSTITUTION: A packed-bed bioreactor for producing high concentration spores through solid cultivation comprises a housing(15) with an air inlet(11) in its lower part and an air outlet(12) in its upper part; two sieves(13, 14) installed in the inner lower part of the housing for supporting a solid medium; the solid medium packed in the upper part of the sieves for supplying a habitat of microorganisms; a plurality of thermocouples(18, 19, 20, 21, 22, 23, 24, 25) installed in the inner side wall and upper wall of the housing for detecting the inner temperature of the solid medium; and a jacket(16) using a water bath(17) installed along the outer wall of the housing for controlling the inner temperature of the housing.