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4-ARYLQUINAZOLINES AND USE THEREOF AS NHE-3 INHIBITORS
4-ARYLQUINAZOLINES AND USE THEREOF AS NHE-3 INHIBITORS
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机译:4-芳基喹唑啉类及其用作NHE-3抑制剂
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摘要
The invention relates to compounds of the formula (I) in which Ar is X-substituted phenyl or naphthyl, which is additionally substituted by R3 and R4, Y or X is H, NR6R7 or a saturated 5-7-membered ring having two N atoms, R1, R2, R3 and R4 are each, independently of one another, H, A, OA, Hal, CF3, OH, NO2, NH2, NHA, NA2, NH-CO-A, NH-CO-Ph, SA, SO-A, SO2-A, SO2-Ph, CN, OCF3, CO-A, CO2H, CO2A, CO-NH2, CO-NHA, CO-NA2, SO2NH2, SO2NHA, SO2NA2, or phenyl which is unsubstituted or monosubstituted or polysubstituted by A, OA, Hal or CF3, and salts and solvates thereof, and to the use thereof as NHE-3 inhibitors.
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