(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione from the Fruiting Bodies of Isaria japonica and apoptosis-inducing composition containing the same

摘要

PURPOSE: Provided is a novel compound, (3R,6R)-4-methyl-6-(1-methylethyl)-phenylethyl-1,4-perhydroxazine-2,5-dione(MMPP O), separated from fruit body extract of Isaria japonica Yasuda and inducing apoptosis. The compound is represented by the formula 1 and is used as an anti-cancer agent. CONSTITUTION: A composition containing the compound, (3R,6R)-4-methyl-6-(1-methylethyl)-phenylethyl-1,4-perhydroxazine-2,5-dione(MMPP O) characteristically leads to apoptosis in the cancer cell of leukemia, breast cancer, liver cancer, stomach cancer, ovary cancer, urinary bladder cancer, lung cancer and epithelioma cancer.