METHOD FOR INHIBITION OF RAF KINASE-MEDIATED GROWTH OF TUMOR CELLS, HETEROCYCLIC UREA DERIVATIVES (VARIANTS), PHARMACEUTICAL COMPOSITION (VARIANTS)

摘要

FIELD: organic chemistry, medicine, biochemistry, pharmacy.;SUBSTANCE: invention relates to a method for inhibition of RAF kinase-mediated growth of tumor cells that involves administration of derivatives of substituted urea of the formula (I):; ;heterocyclic derivatives of urea of the formula (I) and pharmaceutical composition comprising derivatives of urea of the formula (I). Invention provides enhanced effectiveness of inhibition.;EFFECT: improved inhibition method, valuable medicinal properties of compounds.;79 cl, 5 tbl, 58 ex