dicarboxylato diamine platinum derivatives and compositions containing such as anti-cancer agents

摘要

The present invention relates to an antitumor derivative of double dicarboxylic acid diaminoplatin complex of formula (I): CHEM wherein R1 and R2 have the meanings defined in the specification, also relates to a process for preparation thereof, to an antitumor pharmaceutical composition containing the same, and further to application of the derivative in making antitumor pharmaceutics. The composition is a new generation of safe and effective antitumor drug, which has advantages such as low toxicity, broad antitumor spectrum, high antitumor activity, good solubility in water and fine stability in aqueous solution, selective killing of cancer cells without damaging normal cells, etc.