USE OF SKIN PENETRATION PROMOTERS AND MEANS SUITABLE FOR DESTRUCTING THE UPPER SKIN LAYERS TO INCREASE THE IMMUNE RESPONSE INDUCED BY ADP-RIBOSYLATING-EXOTOXIN

摘要

Disclosed is a formulation comprising an antigen and an adjuvant for transcutancous immunization of a subject, wherein the antigen induces an immune response specific for the antigen following application of the formulation to the subject's unperforated skin which is treated to disrupt the stratum corneum.